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Target
Cytochrome P450 2D6
Ligand
BDBM50177525
Substrate
n/a
Meas. Tech.
ChEMBL_334181 (CHEMBL866475)
IC50
1000±n/a nM
Citation
 Berlin, M; Ting, PC; Vaccaro, WD; Aslanian, R; McCormick, KD; Lee, JF; Albanese, MM; Mutahi, MW; Piwinski, JJ; Shih, NY; Duguma, L; Solomon, DM; Zhou, W; Sher, R; Favreau, L; Bryant, M; Korfmacher, WA; Nardo, C; West, RE; Anthes, JC; Williams, SM; Wu, RL; Susan She, H; Rivelli, MA; Corboz, MR; Hey, JA Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:989-94 (2006) [PubMed]  Article 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50177525
Synonyms:
1-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-one | CHEMBL203912
Type:
Small organic molecule
Emp. Form.:
C24H34N4O2
Mol. Mass.:
410.5524
SMILES:
O=C(CCOc1ccc(CN2CCCCC2)cc1)N1CCC(Cc2cnc[nH]2)CC1
Structure:
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