Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50177547
Substrate
n/a
Meas. Tech.
ChEMBL_334179 (CHEMBL866473)
Ki
33±n/a nM
Citation
 Berlin, M; Ting, PC; Vaccaro, WD; Aslanian, R; McCormick, KD; Lee, JF; Albanese, MM; Mutahi, MW; Piwinski, JJ; Shih, NY; Duguma, L; Solomon, DM; Zhou, W; Sher, R; Favreau, L; Bryant, M; Korfmacher, WA; Nardo, C; West, RE; Anthes, JC; Williams, SM; Wu, RL; Susan She, H; Rivelli, MA; Corboz, MR; Hey, JA Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists. Bioorg Med Chem Lett 16:989-94 (2006) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50177547
Synonyms:
CHEMBL381717 | N,N-dimethyl-3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-amine
Type:
Small organic molecule
Emp. Form.:
C17H28N2O
Mol. Mass.:
276.417
SMILES:
CN(C)CCCOc1ccc(CN2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: