Reaction Details Report a problem with these data
Target
GTPase KRas
Ligand
BDBM50503649
Substrate
n/a
Meas. Tech.
ChEMBL_2231968 (CHEMBL5145740)
Ki
200000±n/a nM
Citation
 Zheng, Q; Peacock, DM; Shokat, KM Drugging the Next Undruggable KRAS Allele-Gly12Asp. J Med Chem 65:3119-3122 (2022) [PubMed] 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50503649
Synonyms:
CHEMBL4476113
Type:
Small organic molecule
Emp. Form.:
C22H29ClN4O3
Mol. Mass.:
432.944
SMILES:
CC1(CC1)c1cc(NCC(=O)N2CCN(CC2)C2CN(C2)C(=O)C=C)c(O)cc1Cl
Structure:
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