Reaction Details Report a problem with these data
Target
GTPase KRas
Ligand
BDBM50585384
Substrate
n/a
Meas. Tech.
ChEMBL_2231971 (CHEMBL5145743)
Kd
36000±n/a nM
Citation
 Zheng, Q; Peacock, DM; Shokat, KM Drugging the Next Undruggable KRAS Allele-Gly12Asp. J Med Chem 65:3119-3122 (2022) [PubMed] 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50585384
Synonyms:
CHEMBL5084171
Type:
Small organic molecule
Emp. Form.:
C27H28ClFN6O
Mol. Mass.:
507.002
SMILES:
CN1CCC[C@H]1COc1nc(N2CCNCC2)c2cnc(c(F)c2n1)-c1cccc2cccc(Cl)c12 |r|
Structure:
Search PDB for entries with ligand similarity: