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Target
Sterol O-acyltransferase 2
Ligand
BDBM50177891
Substrate
n/a
Meas. Tech.
ChEMBL_326287 (CHEMBL864498)
IC50
2070±n/a nM
Citation
 Gelain, A; Bettinelli, I; Barlocco, D; Kwon, BM; Jeong, TS; Cho, KH; Toma, L Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors. J Med Chem 48:7708-13 (2005) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 2
Synonyms:
ACACT2 | ACAT-2 | ACAT2 | Acetyl-CoA acetyltransferase, cytosolic | Acetyl-CoA transferase-like protein | Acyl coenzyme A:cholesterol acyltransferase 2 | Cholesterol acyltransferase 2 | Cytosolic acetoacetyl-CoA thiolase | SOAT2 | SOAT2_HUMAN
Type:
Enzyme
Mol. Mass.:
59912.75
Organism:
Homo sapiens (Human)
Description:
O75908
Residue:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
  
Inhibitor
Name:
BDBM50177891
Synonyms:
CHEMBL200625 | N-(2,4-difluorophenyl)-N'-heptyl-N'-{5-[(6-phenyl-pyridazin-3-yl)amino]pentyl}urea
Type:
Small organic molecule
Emp. Form.:
C29H37F2N5O
Mol. Mass.:
509.6338
SMILES:
CCCCCCCN(CCCCCNc1ccc(nn1)-c1ccccc1)C(=O)Nc1ccc(F)cc1F
Structure:
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