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Target
Sterol O-acyltransferase 1
Ligand
BDBM50177892
Substrate
n/a
Meas. Tech.
ChEMBL_326285 (CHEMBL864496)
IC50
2320±n/a nM
Citation
 Gelain, A; Bettinelli, I; Barlocco, D; Kwon, BM; Jeong, TS; Cho, KH; Toma, L Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors. J Med Chem 48:7708-13 (2005) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50177892
Synonyms:
CHEMBL371677 | N-(2,4-difluorophenyl)-N'-heptyl-N'-{5-[(5,6-diphenyl-pyridazin-3-yl)amino]pentyl}urea
Type:
Small organic molecule
Emp. Form.:
C35H41F2N5O
Mol. Mass.:
585.7297
SMILES:
CCCCCCCN(CCCCCNc1cc(-c2ccccc2)c(nn1)-c1ccccc1)C(=O)Nc1ccc(F)cc1F
Structure:
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