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Target
Holo-[acyl-carrier-protein] synthase
Ligand
BDBM25902
Substrate
n/a
Meas. Tech.
ChEMBL_326222 (CHEMBL867576)
IC50
12700±n/a nM
Citation
 Joseph-McCarthy, D; Parris, K; Huang, A; Failli, A; Quagliato, D; Dushin, EG; Novikova, E; Severina, E; Tuckman, M; Petersen, PJ; Dean, C; Fritz, CC; Meshulam, T; DeCenzo, M; Dick, L; McFadyen, IJ; Somers, WS; Lovering, F; Gilbert, AM Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors. J Med Chem 48:7960-9 (2005) [PubMed]  Article 
Target
Name:
Holo-[acyl-carrier-protein] synthase
Synonyms:
ACPS_BACSU | Holo-[acyl-carrieir-protein] synthase | acpS | ydcB
Type:
PROTEIN
Mol. Mass.:
13724.66
Organism:
Bacillus subtilis
Description:
ChEMBL_326222
Residue:
121
Sequence:
MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEKRKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVSITHTKEYAAAQVVIERLSS
  
Inhibitor
Name:
BDBM25902
Synonyms:
4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid | CHEMBL35 | Frusemide | Furanthril | Furosemide | Furosemide (3) | Furosemide, 4 | Lasix | US10172837, Furosemide
Type:
Small organic molecule
Emp. Form.:
C12H11ClN2O5S
Mol. Mass.:
330.744
SMILES:
NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
Structure:
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