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Target
RuvB-like 1
Ligand
BDBM50600250
Substrate
n/a
Meas. Tech.
ChEMBL_2233418 (CHEMBL5147190)
IC50
>66000±n/a nM
Citation
 Zhang, G; Wang, F; Li, S; Cheng, KW; Zhu, Y; Huo, R; Abdukirim, E; Kang, G; Chou, TF Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem 62:0 (2022) [PubMed] 
Target
Name:
RuvB-like 1
Synonyms:
49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | INO80 complex subunit H | INO80H | NMP 238 | NMP238 | Nuclear matrix protein 238 | Pontin 52 | RUVB1_HUMAN | RUVBL1 | TAP54-alpha | TIP49 | TIP49A | TIP60-associated protein 54-alpha
Type:
PROTEIN
Mol. Mass.:
50226.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108308
Residue:
456
Sequence:
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESLQKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
  
Inhibitor
Name:
BDBM50600250
Synonyms:
CHEMBL5171082
Type:
Small organic molecule
Emp. Form.:
C28H29F2N5O
Mol. Mass.:
489.5596
SMILES:
Cc1ccc(Cc2c(C)nc3c(cnn3c2C)C(=O)N2CCN(CC2)c2cccc(c2)C(F)F)cc1
Structure:
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