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Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50600293
Substrate
n/a
Meas. Tech.
ChEMBL_2233556 (CHEMBL5147328)
Kd
301±n/a nM
Citation
 Hao, Y; Shao, H; Qu, Z; Li, J; Shi, Y; Zhang, W; Yu, J; Fu, P; Zhuang, C Investigation on the chemical space of the substituted triazole thio-benzoxazepinone RIPK1 inhibitors. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM50600293
Synonyms:
CHEMBL5183211
Type:
Small organic molecule
Emp. Form.:
C24H25N5O2S
Mol. Mass.:
447.553
SMILES:
CN1c2ccccc2OC[C@H](NC(=O)c2nc(Cc3ccccc3)n(n2)C2CCC2)C1=S |r|
Structure:
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