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Target
Sodium channel protein type 7 subunit alpha
Ligand
BDBM50017659
Substrate
n/a
Meas. Tech.
ChEMBL_2233922 (CHEMBL5147694)
IC50
56±n/a nM
Citation
 Patel, MV; Peltier, HM; Matulenko, MA; Koenig, JR; C Scanio, MJ; Gum, RJ; El-Kouhen, OF; Fricano, MM; Lundgaard, GL; Neelands, T; Zhang, XF; Zhan, C; Pai, M; Ghoreishi-Haack, N; Hudzik, T; Gintant, G; Martin, R; McGaraughty, S; Xu, J; Bow, D; Kalvass, JC; Kym, PR; DeGoey, DA; Kort, ME Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Na Bioorg Med Chem 63:0 (2022) [PubMed] 
Target
Name:
Sodium channel protein type 7 subunit alpha
Synonyms:
Putative voltage-gated sodium channel subunit alpha Nax | SCN6A | SCN7A | SCN7A_HUMAN | Sodium channel protein cardiac and skeletal muscle subunit alpha | Sodium channel protein type 7 subunit alpha | Sodium channel protein type VII subunit alpha
Type:
PROTEIN
Mol. Mass.:
193514.99
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105639
Residue:
1682
Sequence:
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI
  
Inhibitor
Name:
BDBM50017659
Synonyms:
2-(Dimethylamino)ethyl p-(butylamino)benzoate | 2-(dimethylamino)ethyl 4-(butylamino)benzoate | CHEMBL698 | Diaethylaminoaethanol ester der p-butylaminobenzoesaeure | TETRACAINE | p-Butylaminobenzoyl-2-dimethylaminoethanol
Type:
Small organic molecule
Emp. Form.:
C15H24N2O2
Mol. Mass.:
264.3633
SMILES:
CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Structure:
Search PDB for entries with ligand similarity: