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Target
Bile salt-activated lipase
Ligand
BDBM50179326
Substrate
n/a
Meas. Tech.
ChEMBL_325182 (CHEMBL861460)
Ki
4300±n/a nM
Citation
 Pietsch, M; Gütschow, M Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition. J Med Chem 48:8270-88 (2005) [PubMed]  Article 
Target
Name:
Bile salt-activated lipase
Synonyms:
CEL | CEL_BOVIN | Cholesterol esterase
Type:
PROTEIN
Mol. Mass.:
65152.77
Organism:
Bos taurus
Description:
ChEMBL_154778
Residue:
597
Sequence:
LGASRLGPSPGCLAVASAAKLGSVYTEGGFVEGVNKKLSLFGDSIDIFKGIPFAAAPKALEKPERHPGWQGTLKAKSFKKRCLQATLTQDSTYGNEDCLYLNIWVPQGRKEVSHDLPVMIWIYGGAFLMGASQGANFLSNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDSNLPGNYGLWDQHMAIAWVKRNIEAFGGDPDNITLFGESAGGASVSLQTLSPYNKGLIKRAISQSGVGLCPWAIQQDPLFWAKRIAEKVGCPVDDTSKMAGCLKITDPRALTLAYKLPLGSTEYPKLHYLSFVPVIDGDFIPDDPVNLYANAADVDYIAGTNDMDGHLFVGMDVPAINSNKQDVTEEDFYKLVSGLTVTKGLRGANATYEVYTEPWAQDSSQETRKKTMVDLETDILFLIPTKIAVAQHKSHAKSANTYTYLFSQPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFARTGDPNTGHSTVPANWDPYTLEDDNYLEINKQMDSNSMKLHLRTNYLQFWTQTYQALPTVTSAGASLLPPEDNSQASPVPPADNSGAPTEPSAGDSEVAQMPVVIGF
  
Inhibitor
Name:
BDBM50179326
Synonyms:
2-(diethylamino)-5,6-dimethyl-4H-thieno[2,3-d][1,3]oxazin-4-one | 2-Diethylamino-5,6-dimethyl-thieno[2,3-d][1,3]oxazin-4-one | CHEMBL444837
Type:
Small organic molecule
Emp. Form.:
C12H16N2O2S
Mol. Mass.:
252.333
SMILES:
CCN(CC)c1nc2sc(C)c(C)c2c(=O)o1
Structure:
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