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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50179468
Substrate
n/a
Meas. Tech.
ChEMBL_339209 (CHEMBL866556)
Ki
30±n/a nM
Citation
 Tian, X; Chen, X; Gan, L; Hayes, JC; Switzer, AG; Solinsky, MG; Ebetino, FH; Wos, JA; Pinney, BB; Farmer, JA; Crossdoersen, D; Sheldon, RJ Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett 16:1721-5 (2006) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
  
Inhibitor
Name:
BDBM50179468
Synonyms:
(S)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-benzyl-2-[(2S,4R)-4-benzyloxy-2-(3-guanidino-propyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-amide | CHEMBL206033
Type:
Small organic molecule
Emp. Form.:
C34H42N6O3
Mol. Mass.:
582.7357
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#6@H](-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6@H]-1-[#6]-c2ccccc2-[#6]-[#7]-1)-[#8]-[#6]-c1ccccc1
Structure:
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