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Target
Thrombopoietin receptor
Ligand
BDBM50179473
Substrate
n/a
Meas. Tech.
ChEMBL_338314 (CHEMBL866538)
EC50
10000±n/a nM
Citation
 Safonov, IG; Heerding, DA; Keenan, RM; Price, AT; Erickson-Miller, CL; Hopson, CB; Levin, JL; Lord, KA; Tapley, PM New benzimidazoles as thrombopoietin receptor agonists. Bioorg Med Chem Lett 16:1212-6 (2006) [PubMed]  Article 
Target
Name:
Thrombopoietin receptor
Synonyms:
C-mpl | CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | TPO-R | TPOR | TPOR_HUMAN
Type:
PROTEIN
Mol. Mass.:
71243.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_535587
Residue:
635
Sequence:
MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
  
Inhibitor
Name:
BDBM50179473
Synonyms:
2-((2-(6-(4-tert-butylphenyl)pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methyl)malonic acid | CHEMBL202796
Type:
Small organic molecule
Emp. Form.:
C26H25N3O4
Mol. Mass.:
443.4944
SMILES:
CC(C)(C)c1ccc(cc1)-c1cccc(n1)-c1nc2ccc(CC(C(O)=O)C(O)=O)cc2[nH]1
Structure:
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