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Target
Forkhead box protein O1
Ligand
BDBM50600522
Substrate
n/a
Meas. Tech.
ChEMBL_2234444 (CHEMBL5148216)
IC50
33±n/a nM
Citation
 Schade, D; Drowley, L; Wang, QD; Plowright, AT; Greber, B Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes. Bioorg Med Chem 65:0 (2022) [PubMed] 
Target
Name:
Forkhead box protein O1
Synonyms:
FKHR | FOXO1 | FOXO1A | FOXO1_HUMAN
Type:
PROTEIN
Mol. Mass.:
69663.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_525852
Residue:
655
Sequence:
MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPSASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGTMMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPGLLKELLTSDSPPHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKMMNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALGGYSSVSSCNGYGRMGLLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG
  
Inhibitor
Name:
BDBM50600522
Synonyms:
CHEMBL5192734
Type:
Small organic molecule
Emp. Form.:
C18H22FN3O3
Mol. Mass.:
347.384
SMILES:
CCn1cc(C(O)=O)c(=O)c2c(N)c(F)c(NC3CCCCC3)cc12
Structure:
Search PDB for entries with ligand similarity: