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Target
RNA-binding protein FXR2
Ligand
BDBM50572221
Substrate
n/a
Meas. Tech.
ChEMBL_2234715 (CHEMBL5148487)
EC50
84±n/a nM
Citation
 Nara, SJ; Jogi, S; Cheruku, S; Kandhasamy, S; Jaipuri, F; Kathi, PK; Reddy, S; Sarodaya, S; Cook, EM; Wang, T; Sitkoff, D; Rossi, KA; Ruzanov, M; Kiefer, SE; Khan, JA; Gao, M; Reddy, S; Sivaprasad Lvj, S; Sane, R; Mosure, K; Zhuo, X; Cao, GG; Ziegler, M; Azzara, A; Krupinski, J; Soars, MG; Ellsworth, BA; Wacker, DA Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem 65:8948-8960 (2022) [PubMed] 
Target
Name:
RNA-binding protein FXR2
Synonyms:
FMR1 autosomal homolog 2 | FMR1L2 | FXR2 | FXR2P | FXR2_HUMAN | Synonyms=FMR1L2
Type:
PROTEIN
Mol. Mass.:
74219.92
Organism:
Homo sapiens
Description:
ChEMBL_120675
Residue:
673
Sequence:
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELSAPLELGSMVNGVS
  
Inhibitor
Name:
BDBM50572221
Synonyms:
CHEMBL4862974
Type:
Small organic molecule
Emp. Form.:
C30H23Cl2F3N4O3
Mol. Mass.:
615.43
SMILES:
OC(=O)c1cc(c2cc(ccc2n1)N1CCC2(CC(=C2)c2c(onc2-c2c(Cl)cncc2Cl)C2CC2)CC1)C(F)(F)F |c:20,(46.96,-23.25,;46.47,-24.71,;47.49,-25.87,;44.96,-25.01,;44.46,-26.48,;42.95,-26.78,;41.94,-25.62,;40.43,-25.91,;39.43,-24.74,;39.93,-23.29,;41.43,-22.99,;42.44,-24.16,;43.95,-23.86,;37.92,-25.03,;37.41,-26.48,;35.91,-26.76,;34.9,-25.6,;33.89,-24.44,;32.72,-25.45,;33.74,-26.62,;31.19,-25.35,;30.71,-23.88,;29.16,-23.89,;28.69,-25.36,;29.95,-26.26,;29.96,-27.8,;28.63,-28.57,;27.29,-27.8,;28.63,-30.11,;29.96,-30.88,;31.3,-30.11,;31.29,-28.56,;32.62,-27.79,;31.6,-22.64,;33.01,-22.01,;31.76,-21.1,;35.4,-24.15,;36.91,-23.86,;42.45,-28.23,;43.47,-29.39,;40.97,-27.83,;41.68,-29.57,)|
Structure:
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