Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50600748
Substrate
n/a
Meas. Tech.
ChEMBL_2234751 (CHEMBL5148523)
Ki
0.081000±n/a nM
Citation
 Liu, S; Ding, W; Huang, W; Zhang, Z; Guo, Y; Zhang, Q; Wu, L; Li, Y; Qin, R; Li, J; Shi, T; Zhang, X; Lei, J; Hu, W Discovery of Novel Benzo[4,5]imidazo[1,2- J Med Chem 65:8933-8947 (2022) [PubMed] 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50600748
Synonyms:
CHEMBL5176737
Type:
Small organic molecule
Emp. Form.:
C17H14N6O
Mol. Mass.:
318.3327
SMILES:
Nc1nc(cn2c1nc1ccccc21)C(=O)NCc1ccccn1
Structure:
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