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Target
Serine/threonine-protein kinase PknG
Ligand
BDBM50600798
Substrate
n/a
Meas. Tech.
ChEMBL_2234893 (CHEMBL5148665)
Kd
11000±n/a nM
Citation
 Burastero, O; Defelipe, LA; Gola, G; Tateosian, NL; Lopez, ED; Martinena, CB; Arcon, JP; Traian, MD; Wetzler, DE; Bento, I; Barril, X; Ramirez, J; Marti, MA; Garcia-Alai, MM; Turjanski, AG Cosolvent Sites-Based Discovery of  J Med Chem 65:9691-9705 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase PknG
Synonyms:
2.7.11.1 | PKNG_MYCTU | pknG
Type:
PROTEIN
Mol. Mass.:
81567.31
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_102879
Residue:
750
Sequence:
MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDRMATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSETKGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRINSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTLDSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVWYRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTNDGVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQIRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEASLRSLARVAPTQRHRYTLVDMANKVRPTSTF
  
Inhibitor
Name:
BDBM50600798
Synonyms:
CHEMBL5200480
Type:
Small organic molecule
Emp. Form.:
C19H19N3O2
Mol. Mass.:
321.3731
SMILES:
CC(C)c1ccc(cc1)C(=O)c1c(N)c(C(N)=O)c2ccccn12
Structure:
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