Reaction Details Report a problem with these data
Target
Phosphotransferase
Ligand
BDBM50138049
Substrate
n/a
Meas. Tech.
ChEMBL_330068 (CHEMBL865780)
IC50
1450±n/a nM
Citation
Hudock, MP; Sanz-Rodríguez, CE; Song, Y; Chan, JM; Zhang, Y; Odeh, S; Kosztowski, T; Leon-Rossell, A; Concepción, JL; Yardley, V; Croft, SL; Urbina, JA; Oldfield, E Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. J Med Chem 49:215-23 (2006) [PubMed] Article
More Info.:
Target
Name:
Phosphotransferase
Synonyms:
Hexokinase
Type:
PROTEIN
Mol. Mass.:
52180.94
Organism:
Trypanosoma cruzi
Description:
ChEMBL_330068
Residue:
471
Sequence:
MSARLNNLLQHIAVKDKDSDTMRHLKQRMALASLANQFTVGKDHLKQLMLYMVHQMIEGLEGRESTLRMLPSYVYKTDPSKATGVFYALDLGGTNFRVLRVTCKEGRVADRVDAKFVIPQQALQGTAEDLFGFIAQSVKKMMEQKAPEDLNRTVPLGFTFSFPTEQKGVDHGFLIKWTKGFSTRGVEGKDVVELLQKALKRMEVKVKVVALCNDTVGTLITNYFFDPDTQVGVIIGTGSNACYFEDAYAVTKEPSVAARGTTQTPINMECGNFDSKYKFVLPVTAYDEAMDAVTPNRNFQTQEKMVSGMYLGEISRRMIAHLAELHCLPSALASKMAKPWSFETKFMGMISADRMPGLQFTRQVFQELFQVDVTDVADLHVIRDVCCLVRGRAAQISAMFCSAPLVKTRKEGRATVAIDGSVFEKTPSFRRLLQQNMNAILGPGCDVTTALARDGSGIGAAFISALVVNDK
Inhibitor
Name:
BDBM50138049
Synonyms:
(4-heptylphenylamino)methylenediphosphonic acid | CHEMBL433833 | [(4-heptyl-phenylamino)-phosphono-methyl]-phosphonic acid | [(4-heptylphenyl)aminomethylene]-1,1-bisphosphonate
Type:
Small organic molecule
Emp. Form.:
C14H25NO6P2
Mol. Mass.:
365.2989
SMILES:
CCCCCCCc1ccc(NC(P(O)(O)=O)P(O)(O)=O)cc1