Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 5
Ligand
BDBM50601265
Substrate
n/a
Meas. Tech.
ChEMBL_2236096 (CHEMBL5149868)
EC50
480±n/a nM
Citation
 Seenadera, SPD; Long, SA; Akee, R; Bermudez, G; Parsonage, G; Strope, J; Peer, C; Figg, WD; Parker, KA; Beech, DJ; Beutler, JA Biological Effects of Modifications of the Englerin A Glycolate. ACS Med Chem Lett 13:1472-1476 (2022) [PubMed] 
Target
Name:
Short transient receptor potential channel 5
Synonyms:
TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5)
Type:
Enzyme
Mol. Mass.:
111421.47
Organism:
Homo sapiens (Human)
Description:
Q9UL62
Residue:
973
Sequence:
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
  
Inhibitor
Name:
BDBM50601265
Synonyms:
CHEMBL5177160
Type:
Small organic molecule
Emp. Form.:
C28H36O7
Mol. Mass.:
484.5812
SMILES:
[H][C@@]12CC[C@@H](C)[C@@]1([H])[C@H](OC(=O)\C=C\c1ccccc1)[C@@]1(C[C@@H](OC(=O)COC(C)=O)[C@@]2(C)O1)C(C)C |r|
Structure:
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