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Target
3-oxoacyl-[acyl-carrier-protein] synthase 2
Ligand
BDBM50601420
Substrate
n/a
Meas. Tech.
ChEMBL_2236472 (CHEMBL5150368)
IC50
290±n/a nM
Citation
 Troudi, A; Pagès, JM; Brunel, JM Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses. J Med Chem 64:1816-1834 (2021) [PubMed] 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 2
Synonyms:
2.3.1.179 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 3-oxoacyl-[acyl-carrier-protein] synthase II | Beta-ketoacyl-ACP synthase II | FABF_STAAU | KAS II | fabF
Type:
PROTEIN
Mol. Mass.:
42419.21
Organism:
Staphylococcus aureus
Description:
ChEMBL_100958
Residue:
403
Sequence:
VITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHIDKKEARRMDRFTQYAIVAAREAVKDAQLDINENTADRIGVWIGSGIGGMETFEIAHKQLMDKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQRGDADAMITGGTEAPITHMAIAGFSASRALSTNDDIETACRPFQEGRDGFVMGEGAGILVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIKDSKIAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFK
  
Inhibitor
Name:
BDBM50601420
Synonyms:
CHEMBL5176415
Type:
Small organic molecule
Emp. Form.:
C24H27NO7
Mol. Mass.:
441.4737
SMILES:
C[C@]12CC34C[C@H]1C[C@H](O2)[C@H]3[C@](C)(CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)C(=O)C=C4 |r,c:34|
Structure:
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