Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM50181812
Substrate
n/a
Meas. Tech.
ChEMBL_332032 (CHEMBL859597)
EC50
2.7±n/a nM
Citation
 Hart, ME; Suchland, KL; Miyakawa, M; Bunzow, JR; Grandy, DK; Scanlan, TS Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem 49:1101-12 (2006) [PubMed]  Article 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM50181812
Synonyms:
CHEMBL382580 | O-(p-fluoro)phenyl-3-iodotyramine
Type:
Small organic molecule
Emp. Form.:
C15H15FINO
Mol. Mass.:
371.1886
SMILES:
CNCCc1ccc(Oc2ccc(F)cc2)c(I)c1
Structure:
Search PDB for entries with ligand similarity: