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Target
Proteasome subunit beta type-10
Ligand
BDBM50277889
Substrate
n/a
Meas. Tech.
ChEMBL_2237802 (CHEMBL5151698)
IC50
13±n/a nM
Citation
 Klein, M; Busch, M; Friese-Hamim, M; Crosignani, S; Fuchss, T; Musil, D; Rohdich, F; Sanderson, MP; Seenisamy, J; Walter-Bausch, G; Zanelli, U; Hewitt, P; Esdar, C; Schadt, O Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (?5i). J Med Chem 64:10230-10245 (2021) [PubMed] 
Target
Name:
Proteasome subunit beta type-10
Synonyms:
LMP10 | Low molecular mass protein 10 | MECL1 | Macropain subunit MECl-1 | Multicatalytic endopeptidase complex subunit MECl-1 | PSB10_HUMAN | PSMB10 | Proteasome MECl-1 | Proteasome subunit beta-2i
Type:
PROTEIN
Mol. Mass.:
28940.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
273
Sequence:
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
  
Inhibitor
Name:
BDBM50277889
Synonyms:
CARFILZOMIB | CHEMBL451887
Type:
Small organic molecule
Emp. Form.:
C40H57N5O7
Mol. Mass.:
719.9099
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Structure:
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