Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM15579
Substrate
n/a
Meas. Tech.
ChEMBL_2238394 (CHEMBL5152290)
Ki
970±n/a nM
Citation
 Chen, Z; Haider, A; Chen, J; Xiao, Z; Gobbi, L; Honer, M; Grether, U; Arnold, SE; Josephson, L; Liang, SH The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO. J Med Chem 64:17656-17689 (2021) [PubMed] 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM15579
Synonyms:
CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine | SLG | Selegiline | US8633208, Deprenyl | US9469653, Selegiline | methyl[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-ylamine
Type:
Small organic molecule
Emp. Form.:
C13H17N
Mol. Mass.:
187.2808
SMILES:
C[C@H](Cc1ccccc1)N(C)CC#C |r|
Structure:
Search PDB for entries with ligand similarity: