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Target
Sodium/bile acid cotransporter
Ligand
BDBM50113317
Substrate
n/a
Meas. Tech.
ChEMBL_2238515 (CHEMBL5152411)
IC50
7100±n/a nM
Citation
 Chen, S; Zhang, L; Chen, Y; Fu, L Inhibiting Sodium Taurocholate Cotransporting Polypeptide in HBV-Related Diseases: From Biological Function to Therapeutic Potential. J Med Chem 65:12546-12561 (2022) [PubMed] 
Target
Name:
Sodium/bile acid cotransporter
Synonyms:
Bile acid transporter | NTCP | NTCP_HUMAN | SLC10A1
Type:
PROTEIN
Mol. Mass.:
38131.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_838517
Residue:
349
Sequence:
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
  
Inhibitor
Name:
BDBM50113317
Synonyms:
Bis[4-Amino-5-hydroxy-6-(2-methoxy-phenylazo)-naphthalene-1,3-disulfonic acid](Chicago Sky Blue) | CHEMBL311909
Type:
Small organic molecule
Emp. Form.:
C34H28N6O16S4
Mol. Mass.:
904.877
SMILES:
COc1cc(ccc1N=Nc1ccc2c(cc(c(N)c2c1O)S(O)(=O)=O)S(O)(=O)=O)-c1ccc(N=Nc2ccc3c(cc(c(N)c3c2O)S(O)(=O)=O)S(O)(=O)=O)c(OC)c1 |w:9.10,34.36|
Structure:
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