Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50182131
Substrate
n/a
Meas. Tech.
ChEMBL_347009 (CHEMBL864995)
Ki
32000±n/a nM
Citation
 Ahmad, G; Mishra, PK; Gupta, P; Yadav, PP; Tiwari, P; Tamrakar, AK; Srivastava, AK; Maurya, R Synthesis of novel benzofuran isoxazolines as protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett 16:2139-43 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50182131
Synonyms:
3-(4,7-dimethoxybenzofuran-5-yl)-5-(4-methoxyphenyl)-4,5-dihydroisoxazole | CHEMBL377439
Type:
Small organic molecule
Emp. Form.:
C20H19NO5
Mol. Mass.:
353.3686
SMILES:
COc1ccc(cc1)C1CC(=NO1)c1cc(OC)c2occc2c1OC |c:11|
Structure:
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