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Target
Subtilisin-like protease 1
Ligand
BDBM50601911
Substrate
n/a
Meas. Tech.
ChEMBL_2238568 (CHEMBL5152464)
IC50
17000±n/a nM
Citation
 Lidumniece, E; Withers-Martinez, C; Hackett, F; Blackman, MJ; Jirgensons, A Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery. J Med Chem 65:12535-12545 (2022) [PubMed] 
Target
Name:
Subtilisin-like protease 1
Synonyms:
SUB1 | SUB1_PLAFA | Subtilisin-like protease | Subtilisin-like serine protease | sub-1
Type:
PROTEIN
Mol. Mass.:
77866.88
Organism:
Plasmodium falciparum
Description:
ChEMBL_830092
Residue:
690
Sequence:
MMLNKKVVALCTLTLHLFCIFLCLGKEVRSEENGKIQDDAKKIVSELRFLEKVEDVIEKSNIGGNEVDADENSFNPDTEVPIEEIEEIKMRELKDVKEEKNKNDNHNNNNNNNNISSSSSSSSNTFGEEKEEVSKKKKKLRLIVSENHATTPSFFQESLLEPDVLSFLESKGNLSNLKNINSMIIELKEDTTDDELISYIKILEEKGALIESDKLVSADNIDISGIKDAIRRGEENIDVNDYKSMLEVENDAEDYDKMFGMFNESHAATSKRKRHSTNERGYDTFSSPSYKTYSKSDYLYDDDNNNNNYYYSHSSNGHNSSSRNSSSSRSRPGKYHFNDEFRNLQWGLDLSRLDETQELINEHQVMSTRICVIDSGIDYNHPDLKDNIELNLKELHGRKGFDDDNNGIVDDIYGANFVNNSGNPMDDNYHGTHVSGIISAIGNNNIGVVGVDVNSKLIICKALDEHKLGRLGDMFKCLDYCISRNAHMINGSFSFDEYSGIFNSSVEYLQRKGILFFVSASNCSHPKSSTPDIRKCDLSINAKYPPILSTVYDNVISVANLKKNDNNNHYSLSINSFYSNKYCQLAAPGTNIYSTAPHNSYRKLNGTSMAAPHVAAIASLIFSINPDLSYKKVIQILKDSIVYLPSLKNMVAWAGYADINKAVNLAIKSKKTYINSNISNKWKKKSRYLH
  
Inhibitor
Name:
BDBM50601911
Synonyms:
CHEMBL5172494
Type:
Small organic molecule
Emp. Form.:
C20H14Br2ClN5
Mol. Mass.:
519.62
SMILES:
Nc1cc2nc(Nc3ccc(Br)cc3)c(Nc3ccc(Br)cc3)nc2cc1Cl
Structure:
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