Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-6
Ligand
BDBM50540048
Substrate
n/a
Meas. Tech.
ChEMBL_2238691 (CHEMBL5152587)
EC50
38000±n/a nM
Citation
 Teng, M; Young, DW; Tan, Z The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. J Med Chem 65:14289-14304 (2022) [PubMed] 
Target
Name:
NAD-dependent protein deacylase sirtuin-6
Synonyms:
NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6)
Type:
Protein
Mol. Mass.:
39133.03
Organism:
Homo sapiens (Human)
Description:
Q8N6T7
Residue:
355
Sequence:
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
  
Inhibitor
Name:
BDBM50540048
Synonyms:
CHEMBL4636092
Type:
Small organic molecule
Emp. Form.:
C16H13N3
Mol. Mass.:
247.2945
SMILES:
N1C(c2cccn2-c2ccccc12)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: