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Target
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Ligand
BDBM96001
Substrate
n/a
Meas. Tech.
ChEMBL_337022 (CHEMBL867617)
IC50
50000±n/a nM
Citation
 Rogers, JP; Beuscher, AE; Flajolet, M; McAvoy, T; Nairn, AC; Olson, AJ; Greengard, P Discovery of protein phosphatase 2C inhibitors by virtual screening. J Med Chem 49:1658-67 (2006) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Synonyms:
CALNA2 | CALNB | CNA2 | PP2BB_HUMAN | PPP3CB | Serine/threonine protein phosphatase PP2B-alpha catalytic subunit
Type:
PROTEIN
Mol. Mass.:
59017.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_724422
Residue:
524
Sequence:
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ
  
Inhibitor
Name:
BDBM96001
Synonyms:
6,6-dimethyl-1-[4-(4-phenylbutyl)phenyl]-1,3,5-triazine-2,4-diamine;ethanesulfonic acid | CHEMBL99039 | Ethanesulfonic acid, compd. with 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-[p-(4-phenylbutyl)phenyl]-s-triazine (1:1) | MLS002920148 | SMR001797745 | [4-amino-6,6-dimethyl-1-[4-(4-phenylbutyl)phenyl]-s-triazin-2-yl]amine;esylic acid | cid_280522
Type:
Small organic molecule
Emp. Form.:
C21H27N5
Mol. Mass.:
349.4726
SMILES:
CC1(C)N=C(N)N=C(N)N1c1ccc(CCCCc2ccccc2)cc1 |t:3,6|
Structure:
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