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Target
Serine/threonine-protein kinase 16
Ligand
BDBM50603678
Substrate
n/a
Meas. Tech.
ChEMBL_2244959 (CHEMBL5159169)
IC50
>1000±n/a nM
Citation
 Hartz, RA; Ahuja, VT; Nara, SJ; Kumar, CMV; Manepalli, RKVLP; Sarvasiddhi, SK; Honkhambe, S; Patankar, V; Dasgupta, B; Rajamani, R; Muckelbauer, JK; Camac, DM; Ghosh, K; Pokross, M; Kiefer, SE; Brown, JM; Hunihan, L; Gulianello, M; Lewis, M; Lippy, JS; Surti, N; Hamman, BD; Allen, J; Kostich, WA; Bronson, JJ; Macor, JE; Dzierba, CD Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem 65:4121-4155 (2022) [PubMed] 
Target
Name:
Serine/threonine-protein kinase 16
Synonyms:
MPSK1 | PKL12 | STK16 | STK16_HUMAN | Serine/threonine-protein kinase 16 | TSF1 | Tyrosine-protein kinase STK16 (STK16)
Type:
Protein
Mol. Mass.:
34659.07
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
305
Sequence:
MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI
  
Inhibitor
Name:
BDBM50603678
Synonyms:
CHEMBL5202351
Type:
Small organic molecule
Emp. Form.:
C20H20N4
Mol. Mass.:
316.3996
SMILES:
CC(C)C[C@H](N)c1cc(C#N)c2cc(ccc2n1)-c1ccncc1 |r|
Structure:
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