Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50603700
Substrate
n/a
Meas. Tech.
ChEMBL_2244965 (CHEMBL5159175)
Ki
100±n/a nM
Citation
 Klejch, T; Keough, DT; King, G; Dole?elová, E; ?esnek, M; Bud??ínský, M; Zíková, A; Janeba, Z; Guddat, LW; Hocková, D Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J Med Chem 65:4030-4057 (2022) [PubMed] 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50603700
Synonyms:
CHEMBL5171024
Type:
Small organic molecule
Emp. Form.:
C11H15N5Na4O10P2
Mol. Mass.:
531.1709
SMILES:
n/a
Structure:
Search PDB for entries with ligand similarity: