Reaction Details Report a problem with these data
Target
Cholecystokinin receptor type A
Ligand
BDBM50185259
Substrate
n/a
Meas. Tech.
ChEMBL_343639 (CHEMBL860998)
IC50
2800±n/a nM
Citation
 De Luca, S; Saviano, M; Lassiani, L; Yannakopoulou, K; Stefanidou, P; Aloj, L; Morelli, G; Varnavas, A Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their"receptor desmodynamic processes". J Med Chem 49:2456-62 (2006) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47859.34
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-1 receptors in HEK 293 cells.
Residue:
428
Sequence:
MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ
  
Inhibitor
Name:
BDBM50185259
Synonyms:
2(R,S)-{2-[(1H-indole-2-carbonyl)amino]-benzoylamino}propionic acid | 2-(R,S)-{2-[(1H-Indole-2-carbonyl)-amino]-benzoylamino}-propionic acid | CHEMBL380355
Type:
Small organic molecule
Emp. Form.:
C19H17N3O4
Mol. Mass.:
351.356
SMILES:
CC(NC(=O)c1ccccc1NC(=O)c1cc2ccccc2[nH]1)C(O)=O
Structure:
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