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Target
Cysteine protease ATG4B
Ligand
BDBM50604040
Substrate
n/a
Meas. Tech.
ChEMBL_2246463 (CHEMBL5160673)
Ki
4600±n/a nM
Citation
 Kudo, Y; Endo, S; Fujita, M; Ota, A; Kamatari, YO; Tanaka, Y; Ishikawa, T; Ikeda, H; Okada, T; Toyooka, N; Fujimoto, N; Matsunaga, T; Ikari, A Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem 65:4878-4892 (2022) [PubMed] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM50604040
Synonyms:
CHEMBL1358284
Type:
Small organic molecule
Emp. Form.:
C28H44O3
Mol. Mass.:
428.6472
SMILES:
CCCCCCCCCCCCCCCCCCc1ccc(cc1)C(=O)\C=C\C(O)=O
Structure:
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