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Target
Proteasome subunit beta type-5
Ligand
BDBM50604328
Substrate
n/a
Meas. Tech.
ChEMBL_2247505 (CHEMBL5161715)
IC50
572±n/a nM
Citation
 Nan, G; Huang, L; Li, Y; Yang, Y; Yang, Y; Li, K; Lai, F; Chen, X; Xiao, Z Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors. Eur J Med Chem 234:0 (2022) [PubMed] 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50604328
Synonyms:
CHEMBL5180795
Type:
Small organic molecule
Emp. Form.:
C38H44ClN5O5
Mol. Mass.:
686.239
SMILES:
CC(C)(C)NC(=O)CC[C@H](NC(=O)CCNC(=O)CCl)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)NCc1cccc2ccccc12 |r|
Structure:
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