Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 3
Ligand
BDBM50604576
Substrate
n/a
Meas. Tech.
ChEMBL_2248299 (CHEMBL5162509)
Kd
36900±n/a nM
Citation
 Smith, RJ; Perez-Ternero, C; Conole, D; Martin, C; Myers, SH; Hobbs, AJ; Selwood, DL A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem 65:5495-5513 (2022) [PubMed] 
Target
Name:
Atrial natriuretic peptide receptor 3
Synonyms:
ANP-C | ANPR-C | ANPRC | ANPRC_HUMAN | Atrial natriuretic peptide C-type receptor | Atrial natriuretic peptide clearance receptor | Atrial natriuretic peptide receptor | Atrial natriuretic peptide receptor C | C5orf23 | NPR-C | NPR3 | NPRC
Type:
PROTEIN
Mol. Mass.:
59805.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34991
Residue:
541
Sequence:
MPSLLVLTFSPCVLLGWALLAGGTGGGGVGGGGGGAGIGGGRQEREALPPQKIEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDSEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVFQEEGLHTSIYSFDETKDLDLEDIVRNIQASERVVIMCASSDTIRSIMLVAHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNMEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVIAMTDVEAGTQEVIGDYFGKEGRFEMRPNVKYPWGPLKLRIDENRIVEHTNSSPCKSSGGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRTQQEESNLGKHRELREDSIRSHFSVA
  
Inhibitor
Name:
BDBM50604576
Synonyms:
CHEMBL5188425
Type:
Small organic molecule
Emp. Form.:
C21H29ClN6O3
Mol. Mass.:
448.946
SMILES:
CC(C)C[C@H](Nc1nc(Cl)nc(Nc2ccc(NC(C)=O)cc2)n1)C(=O)OC(C)(C)C |r|
Structure:
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