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Target
RNA-directed RNA polymerase
Ligand
BDBM50186150
Substrate
n/a
Meas. Tech.
ChEMBL_369597 (CHEMBL865370)
IC50
9±n/a nM
Citation
 Chris Krueger, A; Madigan, DL; Jiang, WW; Kati, WM; Liu, D; Liu, Y; Maring, CJ; Masse, S; McDaniel, KF; Middleton, T; Mo, H; Molla, A; Montgomery, D; Pratt, JK; Rockway, TW; Zhang, R; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides. Bioorg Med Chem Lett 16:3367-70 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50186150
Synonyms:
CHEMBL208740 | N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxo-4H-1,2,4-benzothiadiazin-7-yl}aminosulfonamide
Type:
Small organic molecule
Emp. Form.:
C20H22N6O6S2
Mol. Mass.:
506.555
SMILES:
CC(C)CCn1c2ncccc2c(O)c(C2=Nc3ccc(NS(N)(=O)=O)cc3S(=O)(=O)N2)c1=O |t:16|
Structure:
Search PDB for entries with ligand similarity: