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Target
RNA-directed RNA polymerase
Ligand
BDBM50222317
Substrate
n/a
Meas. Tech.
ChEMBL_369597 (CHEMBL865370)
IC50
10±n/a nM
Citation
Chris Krueger, A; Madigan, DL; Jiang, WW; Kati, WM; Liu, D; Liu, Y; Maring, CJ; Masse, S; McDaniel, KF; Middleton, T; Mo, H; Molla, A; Montgomery, D; Pratt, JK; Rockway, TW; Zhang, R; Kempf, DJ Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides. Bioorg Med Chem Lett 16:3367-70 (2006) [PubMed] Article
More Info.:
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Inhibitor
Name:
BDBM50222317
Synonyms:
CHEMBL394002 | N-[(4-methoxyphenyl)methyl]({3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxo-4H-1,2,4-benzothiadiazin-7-yl}amino)sulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H30N6O7S2
Mol. Mass.:
626.704
SMILES:
COc1ccc(CNS(=O)(=O)Nc2ccc3N=C(NS(=O)(=O)c3c2)c2c(O)c3cccnc3n(CCC(C)C)c2=O)cc1 |c:16|