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Target
Bcl-2-related protein A1
Ligand
BDBM34194
Substrate
n/a
Meas. Tech.
ChEMBL_2249566 (CHEMBL5163776)
Ki
400±n/a nM
Citation
 Feng, X; Yan, Z; Zhou, F; Lou, J; Lyu, X; Ren, X; Zeng, Z; Liu, C; Zhang, S; Zhu, D; Huang, H; Yang, J; Zhao, Y Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM34194
Synonyms:
3-chloranyl-1-(3,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)pyrrole-2,5-dione | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-methylpiperazino)-3-pyrroline-2,5-quinone | MLS000110530 | PD119792 | SMR000106459 | cid_1180676
Type:
Small organic molecule
Emp. Form.:
C15H14Cl3N3O2
Mol. Mass.:
374.65
SMILES:
CN1CCN(CC1)C1=C(Cl)C(=O)N(C1=O)c1ccc(Cl)c(Cl)c1 |c:8|
Structure:
Search PDB for entries with ligand similarity: