Reaction Details Report a problem with these data
Target
Bcl-2-related protein A1
Ligand
BDBM50511138
Substrate
n/a
Meas. Tech.
ChEMBL_2249570 (CHEMBL5163780)
Ki
680±n/a nM
Citation
 Feng, X; Yan, Z; Zhou, F; Lou, J; Lyu, X; Ren, X; Zeng, Z; Liu, C; Zhang, S; Zhu, D; Huang, H; Yang, J; Zhao, Y Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM50511138
Synonyms:
CHEMBL4576854
Type:
Small organic molecule
Emp. Form.:
C30H37N3O4S2
Mol. Mass.:
567.762
SMILES:
CC(C)(C)c1ccc(CN2CCN(CC2)S(=O)(=O)Nc2ccc(SCCc3ccccc3)cc2C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: