Reaction Details Report a problem with these data
Target
Deoxyuridine triphosphatase, putative
Ligand
BDBM50186258
Substrate
n/a
Meas. Tech.
ChEMBL_366108 (CHEMBL864792)
Ki
>1000000±n/a nM
Citation
 Mc Carthy, OK; Schipani, A; Buendía, AM; Ruiz-Perez, LM; Kaiser, M; Brun, R; Pacanowska, DG; Gilbert, IH Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase. Bioorg Med Chem Lett 16:3809-12 (2006) [PubMed]  Article 
Target
Name:
Deoxyuridine triphosphatase, putative
Synonyms:
Deoxyuridine triphosphatase
Type:
PROTEIN
Mol. Mass.:
38920.01
Organism:
Trypanosoma cruzi
Description:
ChEMBL_366108
Residue:
340
Sequence:
MEAQLRATSFLWHHPLQVSGCLNFLFIYFSSFLFRVLFLFYSTSLLCLFLSVLAVLEMNRVQSSFRVPARVLNSLVHLQDGLNTFMDPDWRQIRHVDDWALAITMESAELIDSYPWKWWKNVKAQADMHNVRIEIADILHFSLSGEMQKRTQDGKGAGDVALKSLKEMGFFCRPPAHAKSTEASDHRTNGGDDDGDDELLELIFFPLTEVASAVATFRNIIQLASIYRFDLITKGLLLAAQDLDFNLVGYYVAKYTLNQIRQLKGYKEGAYVKVREGVEDNELLHECVQSVSVEDVLNEGTYLKTWEKIACSVFDAFGMPEEERRHAYEWLKSAALEGKR
  
Inhibitor
Name:
BDBM50186258
Synonyms:
(S)-2-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)acetamido)-3-(4-hydroxyphenyl)propanoic acid | CHEMBL213599
Type:
Small organic molecule
Emp. Form.:
C17H18N4O7
Mol. Mass.:
390.3474
SMILES:
OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)Cn1ccc(=O)[nH]c1=O
Structure:
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