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Target
Cyclin-dependent kinase 5
Ligand
BDBM50186373
Substrate
n/a
Meas. Tech.
ChEMBL_365588 (CHEMBL870943)
IC50
34±n/a nM
Citation
 Shimamura, T; Shibata, J; Kurihara, H; Mita, T; Otsuki, S; Sagara, T; Hirai, H; Iwasawa, Y Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9. Bioorg Med Chem Lett 16:3751-4 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM50186373
Synonyms:
CHEMBL424696 | N-(5-(2-(cyclohexyloxy)pyrimidin-4-yl)thiazol-2-yl)pyridin-2-amine
Type:
Small organic molecule
Emp. Form.:
C18H19N5OS
Mol. Mass.:
353.441
SMILES:
C1CCC(CC1)Oc1nccc(n1)-c1cnc(Nc2ccccn2)s1
Structure:
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