Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50605150
Substrate
n/a
Meas. Tech.
ChEMBL_2250526 (CHEMBL5164736)
Kd
3840±n/a nM
Citation
 Zhong, DX; She, MT; Guo, XC; Zheng, BX; Huang, XH; Zhang, YH; Ser, HL; Wong, WL; Sun, N; Lu, YJ Design and synthesis of quinolinium-based derivatives targeting FtsZ for antibacterial evaluation and mechanistic study. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50605150
Synonyms:
CHEMBL5174791
Type:
Small organic molecule
Emp. Form.:
C26H32IN3
Mol. Mass.:
513.4568
SMILES:
[I-].CC1CCN(CC1)c1cc(\C=C\c2ccc(cc2)N(C)C)[n+](C)c2ccccc12
Structure:
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