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Target
Galectin-3
Ligand
BDBM50243731
Substrate
n/a
Meas. Tech.
ChEMBL_2250675 (CHEMBL5164885)
Kd
420000±n/a nM
Citation
 Bum-Erdene, K; Collins, PM; Hugo, MW; Tarighat, SS; Fei, F; Kishor, C; Leffler, H; Nilsson, UJ; Groffen, J; Grice, ID; Heisterkamp, N; Blanchard, H Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. J Med Chem 65:5975-5989 (2022) [PubMed] 
Target
Name:
Galectin-3
Synonyms:
LEG3_HUMAN | LGALS3 | MAC2
Type:
Enzyme
Mol. Mass.:
26156.54
Organism:
Homo sapiens (Human)
Description:
P17931
Residue:
250
Sequence:
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
  
Inhibitor
Name:
BDBM50243731
Synonyms:
(2R,3S,4S,5S,6R)-3-acetoxy-5-hydroxy-6-(hydroxymethyl)-2-methoxy-tetrahydro-2H-pyran-4-yl 4-methylbenzoate | CHEMBL471376
Type:
Small organic molecule
Emp. Form.:
C17H22O8
Mol. Mass.:
354.3518
SMILES:
CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](OC(=O)c2ccc(C)cc2)[C@@H]1OC(C)=O |r|
Structure:
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