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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50605602
Substrate
n/a
Meas. Tech.
ChEMBL_2252302 (CHEMBL5166512)
Ki
35±n/a nM
Citation
 Tian, Y; Shehata, MA; Gauger, SJ; Ng, CKL; Solbak, S; Thiesen, L; Bruus-Jensen, J; Krall, J; Bundgaard, C; Gibson, KM; Wellendorph, P; Frĝlund, B Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKII? Hub Domain. J Med Chem 65:6656-6676 (2022) [PubMed] 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54093.63
Organism:
Homo sapiens (Human)
Description:
gi_25952118
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50605602
Synonyms:
CHEMBL5175277
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2NO3
Mol. Mass.:
312.148
SMILES:
OC(=O)Cc1ccc(O)cc1Nc1c(Cl)cccc1Cl
Structure:
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