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Target
Cyclin-C
Ligand
BDBM50605728
Substrate
n/a
Meas. Tech.
ChEMBL_2252775 (CHEMBL5166985)
IC50
80±n/a nM
Citation
 Yan, Y; Xing, C; Xiao, Y; Shen, X; Zhang, Z; He, C; Shi, JB; Liu, M; Liu, X Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease  J Med Chem 65:7334-7362 (2022) [PubMed] 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50605728
Synonyms:
CHEMBL5178431
Type:
Small organic molecule
Emp. Form.:
C23H22N4O2
Mol. Mass.:
386.4464
SMILES:
O=C(Nc1ccccc1)c1cncc(c1)-c1ccc(cc1)C(=O)N1CCNCC1
Structure:
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