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Target
Mas-related G-protein coupled receptor member X1
Ligand
BDBM50605952
Substrate
n/a
Meas. Tech.
ChEMBL_2253201 (CHEMBL5167411)
EC50
55±n/a nM
Citation
 Sharma, S; Peng, Q; Vadukoot, AK; Aretz, CD; Jensen, AA; Wallick, AI; Dong, X; Hopkins, CR Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1. ACS Med Chem Lett 13:841-847 (2022) [PubMed] 
Target
Name:
Mas-related G-protein coupled receptor member X1
Synonyms:
MRGPRX1 | MRGX1 | MRGX1_HUMAN | SNSR3 | SNSR4
Type:
PROTEIN
Mol. Mass.:
36253.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_516621
Residue:
322
Sequence:
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
  
Inhibitor
Name:
BDBM50605952
Synonyms:
CHEMBL5185447
Type:
Small organic molecule
Emp. Form.:
C18H18ClFN2O4S
Mol. Mass.:
412.863
SMILES:
CCOc1ccc(F)cc1NC(=O)c1cc(Cl)ccc1NS(=O)(=O)C1CC1
Structure:
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