Reaction Details Report a problem with these data
Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50606223
Substrate
n/a
Meas. Tech.
ChEMBL_2254178 (CHEMBL5168388)
IC50
50±n/a nM
Citation
 Wang, W; He, J; Yang, J; Zhang, C; Cheng, Z; Zhang, Y; Zhang, Q; Wang, P; Tang, S; Wang, X; Liu, M; Lu, W; Zhang, HK Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. J Med Chem 65:7896-7917 (2022) [PubMed] 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_MOUSE | PGE receptor, EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4
Type:
G-protein coupled receptor
Mol. Mass.:
56175.66
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
513
Sequence:
MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
  
Inhibitor
Name:
BDBM50606223
Synonyms:
CHEMBL5195058
Type:
Small organic molecule
Emp. Form.:
C25H24FNO4S
Mol. Mass.:
453.526
SMILES:
C[C@H](NC(=O)c1c(CCc2ccc(F)cc2)sc2COCCc12)c1ccc(cc1)C(O)=O |r|
Structure:
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