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Target
Cysteine protease ATG4B
Ligand
BDBM50536833
Substrate
n/a
Meas. Tech.
ChEMBL_2260022 (CHEMBL5215033)
IC50
<100±n/a nM
Citation
 Yang, G; Li, Y; Zhao, Y; Ouyang, L; Chen, Y; Liu, B; Liu, J Targeting Atg4B for cancer therapy: Chemical mediators. Eur J Med Chem 209:0 (2021) [PubMed] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM50536833
Synonyms:
CHEMBL4546760
Type:
Small organic molecule
Emp. Form.:
C23H20F2N2O3
Mol. Mass.:
410.4133
SMILES:
FCC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(F)c2ccccc12 |r|
Structure:
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