Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50189025
Substrate
n/a
Meas. Tech.
ChEMBL_395997 (CHEMBL910342)
EC50
0.34±n/a nM
Citation
 Tian, X; Mishra, RK; Switzer, AG; Hu, XE; Kim, N; Mazur, AW; Ebetino, FH; Wos, JA; Crossdoersen, D; Pinney, BB; Farmer, JA; Sheldon, RJ Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists. Bioorg Med Chem Lett 16:4668-73 (2006) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50189025
Synonyms:
(S)-2-acetamido-N1-((R)-3-(4-fluorophenyl)-1-((S)-2-(3-guanidinopropyl)-4-((S)-1-(methylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-3-oxopiperazin-1-yl)-1-oxopropan-2-yl)pentanediamide | CHEMBL215833
Type:
Small organic molecule
Emp. Form.:
C38H48FN9O6
Mol. Mass.:
745.8428
SMILES:
CNC(=O)[C@H](Cc1ccc2ccccc2c1)N1CCN([C@@H](CCCNC(N)=N)C1=O)C(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](CCC(N)=O)NC(C)=O
Structure:
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