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Target
Cyclin-dependent kinase 4
Ligand
BDBM50606473
Substrate
n/a
Meas. Tech.
ChEMBL_2260098 (CHEMBL5215109)
IC50
1.2±n/a nM
Citation
 Bass, AKA; El-Zoghbi, MS; Nageeb, EM; Mohamed, MFA; Badr, M; Abuo-Rahma, GEA Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors. Eur J Med Chem 209:0 (2021) [PubMed] 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50606473
Synonyms:
CHEMBL5220945
Type:
Small organic molecule
Emp. Form.:
C25H25F2N7O3
Mol. Mass.:
509.5079
SMILES:
CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc(CNC(=O)CC(=O)NO)cc2)ncc1F
Structure:
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