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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50606666
Substrate
n/a
Meas. Tech.
ChEMBL_2261037 (CHEMBL5216048)
IC50
18200±n/a nM
Citation
 Wang, Y; Qin, L; Chen, W; Chen, Q; Sun, J; Wang, G Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1. Eur J Med Chem 226:0 (2021) [PubMed] 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
4F2 LC | 4F2 light chain | 4F2LC | CD98 light chain | CD98LC | CD98LC | Integral membrane protein E16 | L-type amino acid transporter 1 | LAT1 | LAT1_HUMAN | Large neutral amino acids transporter small subunit 1 | MPE16 | SLC7A5 | Solute carrier family 7 member 5 | hLAT1 | y+ system cationic amino acid transporter
Type:
PROTEIN
Mol. Mass.:
55013.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_100160
Residue:
507
Sequence:
MAGAGPKRRALAAPAAEEKEEAREKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPLFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFVQIGKGDVSNLDPNFSFEGTKLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHRKPELERPIKVNLALPVFFILACLFLIAVSFWKTPVECGIGFTIILSGLPVYFFGVWWKNKPKWLLQGIFSTTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50606666
Synonyms:
CHEMBL5219332
Type:
Small organic molecule
Emp. Form.:
C32H27N7O5
Mol. Mass.:
589.6007
SMILES:
CNC(=O)COc1ccc(cc1)C1=C(C#N)C2N=C3C=CC=CC3N2C(NC(=O)c2cccc(C[C@H](N)C(O)=O)c2)=C1C#N |r,c:13,20,22,44,t:18|
Structure:
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